In the Fourth Industrial Revolution, crime is hardly reported to the Police, or other law enforcement agencies. Most victims prefer to go on social media and vent, as this medium is easier for them to access and requires no paperwork or interrogations. This leaves policy makers and the law enforcement with skewed dataset, due to unreported crimes. Hence, it is paramount that one finds a way to “mine” the crime data reported on social media to comprehensively gain insights in crimes that have been committed for decision making. In this paper, we have attempted to estimate crime rates, using one microblogging and social networking service, Twitter as a data source. To do this, we have used a formal technique – Jumping Finite Automata (JFA), for the abstraction of a corpus of crime-related words and leveraged shuffle algorithms to establish semantic relationships between these words. Furthermore, we implemented JFA in a tool called “Crime-Ripper”. Through evaluation, we demonstrate that given real-world tweet dataset, Crime-Ripper is able to estimate crime rates and produce reports that are map annotations, showing areas of a city and their respective estimated crime-rates. Crime-Ripper is expected to find applications in law enforcement, policy making and public safety sensitization.

The overactivation of fibroblasts, which results in their proliferation with overproduction of the extracellular matrix, is a pathophysiological hallmark of hypertrophic scar formation. The intermediate-conductance Ca2+-activated K+ channel (KCa3.1) is involved in fibroblast activation in multiple clinical conditions; however, its role in the post-burn hypertrophic scar formation remains to be determined. In this study, we aimed to investigate the role of KCa3.1 and anti-fibrotic potential of cyclohexadiene lactone, a KCa3.1 blocker, in post-burn hypertrophic scar formation. Cell proliferation and expression of hypertrophic markers were investigated in fibroblasts obtained directly from patients within 1–2 weeks after third-degree burns who consequently developed post-burn hypertrophic scars. The anti-fibrotic effects of cyclohexadiene lactone via KCa3.1 inhibition were assessed using in vitro fibroblasts and in vivo murine burn models. Increased cell proliferation and expression of hypertrophic markers were identified in burn-wound fibroblasts obtained from patients. The targeted inhibition of KCa3.1 by cyclohexadiene lactone markedly decreased cell proliferation along with the expression of hypertrophic markers in burn-wound fibroblasts from patients. In addition, the anti-scarring effect following cyclohexadiene lactone administration was confirmed using murine burn models in terms of molecular, histological, and visual aspects. This study demonstrated altered cellular and molecular responses of skin fibroblasts from patients after third-degree burns. In addition, this study confirmed an anti-fibrotic effect of KCa3.1 inhibition by cyclohexadiene lactone in both in vitro within burn fibroblasts and in vivo within murine burn models. These results suggest that selective inhibition of KCa3.1 by cyclohexadiene lactone has therapeutic potential to prevent hypertrophic scar formation following burns.

Hypertrophic scars are the most common complication resulting from burn injury, and their pathological hallmark is excessive deposition of fibroblast-derived extracellular matrix proteins. Calpain, a calcium-dependent endopeptidase, mediates fibroblast activation and collagen synthesis, leading to the development of certain fibrotic diseases; however, its role in hypertrophic skin scar formation following a burn injury is yet to be determined. In this study, a detailed evaluation of the expression and activity of calpain in skin fibroblasts obtained directly from patients with third-degree burns, who subsequently developed post-burn hypertrophic scars, was performed. Furthermore, the antifibrotic effect of targeted inhibition of calpain by leupeptin on post-burn skin scarring was evaluated in vitro and in vivo. The mRNA and protein expression and activity of calpain were significantly higher in burn wound fibroblasts from patients than in normal cells. Selective inhibition of calpain by leupeptin significantly reduced the proliferation of burn wound fibroblasts as well as the mRNA and protein expression of calpain, transforming growth factor-beta 1, α-smooth muscle actin, type I and type III collagens, fibronectin, and vimentin in these cells. Furthermore, the molecular, histological, and visual effects related to post-burn scar suppression by leupeptin were verified in murine burn models. The results obtained herein highlight the pathophysiological role of calpain and indicate that calpain inhibition by leupeptin could serve as a new therapeutic strategy for preventing hypertrophic scar formation following burns.

The need for resultant measures of the entropy-information content of quantum electronic states in molecular systems, combining the information contributions due to the probability and phase/current distributions, is emphasized. The limitations for the simultaneous removal of uncertainties in the position and current/velocity distributions, imposed by the Heisenberg indeterminacy principle, are discussed, continuities of the wavefunction modulus and phase components are examined, and convectional character of the net source of resultant gradient information is stressed.

Federated cloud is a dynamic environment in which the requirements of users and applications keep on changing reflects in the selection of optimal cloud service provider. One of the critical factors in success of cloud provider is the delivery of services which enabled with promised QoS. The failure of providing the service with promised QoS is known as SLA violation. To manage SLA violations a new architecture for federated cloud is proposed which provided with fault tolerant techniques such as FDSSS and virtual clustering can guarantee the availability and reliability of service in spite of failure to satisfy the requirements of user mentioned in SLA. In the proposed broker architecture, Fault tolerant Designer for SLA Satisfied Service (FDSSS) component is introduced which advances the SLA violations and improve QoS for the users. Natural Inspired Bee algorithm is modified and applied to form virtual clusters among the providers to extend uninterrupted services to the users. The simulation results show that the proposed architecture behaves better in SLA violations and provide better QoS service to the user compared to the existing works

Regardless of the etiologies of hip pain and arthralgy there are two different approach to improve dog’s quality of life by reducing and eliminating the pain including total hip replacement (THR) and femoral head ostectomy(FHO).\nIn THR the surgeon removes and replaces both the ball and socket with prostheses. Most canine hip replacement prostheses have a metal ball at the top of the femur that fits into a dense plastic socket. The prostheses are generally held in place using special bone cement.\nAn FHO, or femoral head ostectomy, is a surgical procedure that aims to restore pain-free mobility to a diseased or damaged hip, by removing the head and neck of the femur (the long leg bone or thighbone). \n\nWe have tried to review the results of both procedures in literatures and compare them to advise to select the proper procedure in your cases.

A honeycomb mesh network with n nodes has degree 3 and diameter= 1.63 √\nn − 1, which is 25 percent smaller degree and 18.5 percent smaller diameter than the mesh-connected computer with approximately the same number of nodes. Vertex and edge symmetric honeycomb torus network is obtained by adding wraparound edges to the honycomb mesh. The network cost, defined as the product of degree and\ndiameter, is better for honeycomb networks than for the two other families based on square (mesh-connected computers and tori) and triangular (hexagonal meshes and tori)tessellations. Meshes are widely used topologies for Networks on Chip(NoC). Honeycomb meshers have better topological properties than Meshes and it is also a popular mesh-derived parallel architectures. A topology is evaluated in terms of a number of parameters. In this paper, we determine vulnerability paramets of honeycomb mesh

The implication of the corporate environmental activities on the corporate growth has been a contentious issue globally. The business activities of the organization affect its internal and external environments. The environment is under threat from the negative consequences resulted from the impact of corporate business activities on the environment. The cognizant of the negative impact of the corporate business activities on the environment globally has intensified the pressure on the corporate globally by the various stakeholders to engage in environmentally friendly business activities. Despite the fact that researches have indicated that it is in the best interest of the business organizations to take measures that would prevent environmental damages, some business organizations are not taking the call seriously. The corporate environmental activities have been linked to its growth. The environmental sensitive business organizations have seen increment in their performance while environmental insensitive business organizations have seen reduction in their performance. This study analyzed the implications of the corporate environmental reporting practice on corporate growth. The relevant literature on corporate environmental disclosure practice and corporate growth was reviewed and discussed, including the theory that underpins the study. It was established in the study that the growth of the business organizations heavily depends on their environmental activities. The study also uses the stakeholder theory to justify the rationale behind taking various stakeholders into consideration during the decision making process and not just only the shareholders. The study’s contribution to knowledge, limitation, and recommendation for further study were also discussed.